​Istanbul Aydın University was established under the guidance of Anatolia Education and Culture Foundation in accordance with the additional article numbered 73 of the law numbered 5656 published in the Official Gazette numbered 26526 on the date of 18.05.2007.  Istanbul Aydın University was established with the experiences gained through an existing university and Anadolu Bil Vocational School of Higher Education founded in 2003 as a result of the bonds established beforehand. In this context, IAU has a unique position in Turkey. The two institutions gathered under the same roof with the establishment of IAU and started to provide associate's degree, bachelor's degree and master's degree education. Both Istanbul Aydın University and Anadolu Bil Vocational School of Higher Education are based on the ground of Anatolia Education and Culture Foundation (AKEV).

Faculty of Health Sciences was established with the decision of the Council of Ministers published in the Official Gazette dated 10.09.2012 and numbered 280407.Istanbul Aydın University Faculty of Health Sciences Nursing Department started education and training in 2013-2014 and gave its first graduate in 2017.